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KMID : 0357919780120040365
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Korean Journal of Pathology
1978 Volume.12 No. 4 p.365 ~ p.374
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Malignant Histiocytosis with Cutaneous Lesions and Eosinophilia -A case report with light and electron ulicroscopic study-
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구혜수/Hea Soo Koo
박문향/박효숙/김진혁/손숙자/신실/Moon Hyang Park/Hyo Sook Park/Jin Hyuk Kim/Sook Ja Son/Shil Shin
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Abstract
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A 70 year-old Korean male was admitted to Dept. of Dermatology, because of
generalized erythematous match head sized papules with itching sensation for 45 days.
Physical examination revealed palpable axillary, inguinal and left sutclavicu1ar lymph
nodes, and slight hepatomegaly. Peripheral blood findings showed marked eoainophilia
(up to 41%) and a few atypical monocytoid cells. Multiple skin biopsies revealed
malignant histiocytosis with cutaneous involvement.
He was treated with oncovin and prednisolone, and skin lesions and hematologic
abnormalities were considerably improved. But the patient was died on 38th hospital
day.
On autopsy, the lesions were systemic, showing diffuse proliferation of atypical
histiocytes with atypical giant cell formation in spleen, lymph nodes, lung, bone marrow
and skin. However, erythrophagocytosis of these atypical histiocytes was not seen.
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KEYWORD
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